different premedication admixture with propofol to attenuate pain severity induced by propofol injection: a double blind randomized clinical trial

Propofol is widely used because it provides pleasant anesthesia and rapid recovery.However pain on injection is one main side effect of propofol continues to be an undesirable problem.This study deal with comparing the effect of thiopental, lidocaine, fentanyl, normal salinecompare with placebo admixture with propofol on injection pain induced by propofol. This double blind clinical trial study was conducted on 257 patients which were randomly allocated to one of five groups to receive only 2mg/kg of propofol type fresenius 1% in group I, 2 cc of lidocaine 1% in group II, 2 ml of normal saline 0.09% in group III, 50 mg sodium thiopental in group IV and group V were injected100 μg fentanyl before injection of Propofol. Verbal Rating Scale was evaluated for documenting pain. A significant decrease in the severity of pain during injection was achieved in group II (thiopental) and IV (lidocaine) campared to the three other group. Fentanyl was also effective to reduce moderate pain. We found thiopental and lidocaine were more effective in reducing the incidence and severity of pain injection than the other three groups. Thus it seems to be more appropriate as an alternative method to diminish propofol injection pain than the other treatments used in this study.