Antimicrobial activity of cholesterol eliminator lactobacilli

The extensive increasing antibiotic resistance in the world made us use natural probiotic compounds as a curing alternative. In this study two lactobaclilli (L. casei and L. acidophilus), which in another survey were determined as the most active probiotics for removing and eliminating cholesterol, were chosen to evaluate their antibacterial activity against pathogens. This case control study had performed on the Lactobacillus isolated strains from the Fars local dairy products. The resistance of the lactobacillus strains to antibiotics was assessed using disk diffusion method. Also, in order to evaluate their ability to inhibite the growth of other pathogens, the obtained supernatant of their 72 hours broth culture have been used by agar diffusion method in both active and inactive condition Although L. casei was resistant to all assayed antibiotics, L. acidophilus was susceptible to tobramycin and vancomycin. Also, the antibacterial studies of the Lactobacilli on several pathogens showed an inhibition zone for most of the assayed pathogens except for B. subtilis. According to the resistance of these two lactobacilli to the ordinary antibiotics and their high antibacterial activities against the nosocomial infections, they are applicable for probiotics purposes.