Preventive effects of hydro-alcoholic extract of Prangos ferulacea (L.) Lindl. on kidney damages of diabetic rats induced by alloxan

Diabetic nephropathy is one of the most important implication factors in kidney´s physiological function in diabetes mellitus. Having major role in filtration، in hyperglycemic condition kidney has shown more damages in comparison with other tissues. The aim of this study was to investigate kidneys histopathological changes during diabetes and nephropatic diabetic conditions. The effect of Prangos ferulacea on these changes was also evaluted In this experimental study (40) female Wistar rats with body weight of 200± 20 gr were randomly divided into 5 groups with 8 rats in each group. Diabetes was induced in rats by intrapritoneally injection of alloxan monohydrate in a dose of 120 mg/kg body weight (BW). Root and leaves with stems hydroalcoholic extract of Prangos ferulacea in a dose of 100 mg/kg B. W were injected orally in diabetic rats daily for 4 weeks. At the end of the treatment، renal tissue samples were processed and histological changes were investigated. Diabetic rats compared with control group showed a significant increase in blood glucose and WBC، and a decrease in body weight. Further، renal tissue complications such as: messential matrix expantion، glumerular basement membrane thickness، glumerular shrinkage and increase in lymphocytic infiltration were observed. In diabetic rats treated by roots of hydroalcoholic extract of Prangos ferulacea (L.) Lindl. all of the previous signes were decreased، significantly (P<0. 05). Conclution: These results showes that root hydroalcoholic extract of prangos ferulacea had useful effects on renal histopathological distruption induced by diabetes.