Comparison of the effect of clonazepam and ondansetron on post operative nausea and vomiting in laparoscopic gynecologic surgery

Decreasing postoperative nausea and vomiting is one of the most important concerns of the anesthesiologist. There are several managements for prevention and/or treatment of this postoperative complication, but none is completely effective, some are relatively expensive (eg, ondansetrone), and others have considerable side effects (eg, steroids). Clonazpam is a benzodiazepine that is effective for treatment of refractory chemotherapy-induced nausea and vomiting in addition to providing good sedation for stressful surgical patients. This study was designed to compare clonazpam with one of the most effective choices ondansetrone. In this randomized clinical trial study, 150 ASA Class I or II patients, scheduled for gynecologic laparoscopic surgeries were selected. They were enrolled according to inclusion & exclusion criteria & randomized in 3 groups, each group comparing of 50 patients. In clonazpam group, 2 mg oral clonazpam was administered 2hour before operation. In ondansetron group, 4 mg IV ondansetron was administered after intubation and control group received placebo. Postoperative nausea and vomiting was evaluated till 12 hours post op in all patients. There was no significant difference between administration, clonazepam or ondansetron or placebo in decreasing of post operation nausea and vomiting in the 3 groups (p>0.05). Adminstration of oral clonazepam compared to intravenous ondansetron or oral placebo in gynecologic laparoscopic surgeries did not decrease the rate of post operative nausea and vomiting.