Comparison of Analgesic and Hypoglycemic Effect of Hexanic and Alcohlic Extract of Fenugreek Seed in Male Diabetic Rats

Diabetes mellitus is recognized with severe metabolic complications. Many herbal medicines have been recommended for treatment of diabetes. In this study, the antidiabetic and analgesic effect of hexanic and alcohlic extract Trigonella-foenum graecum was investigated in normal and streptozotocin-induced diabetic rats. Present study was carried out in 2011 at Guilan University of Medical Sciences, 48 male Sprague Dawley rats (230-300 gr) were divided into six groups: control, type 1 diabetic, and 4 treated groups that received intraperitonealy hexanic and alcoholic extract of fenugreek (100, 200 mg/kg body weight) for 28 days. Two experimental models were used (acetic acid, and hot-plate tests) in order to characterize the analgesic effect. Blood glucose was measured with glucometer. Data analyzed with spss software 16 and one way ANOVA and Tukey tests. P<0.05 was statistically significant. Compared to control rats, both of the aqueous - alcoholic and Hexanic extract significantly reduced blood glucose level in all diabetics groups. This effect was stronger in groups that received Hexanic extract (p <0.05). All groups received the aqueous - alcoholic and Hexanic extract showed analgesic effect but this effect was more clear in the Hexanic 200 mg/kg group (p <0.05). Fenugreek extract possesses hypoglycemic, and analgesic effects.