Effects of glutamine supplementation on enzyme activist, blood parameters, mortality and performance in broiler with pulmonary hyepertension syndrome

A study was conducted to investigate the effects of glutamine on blood parameters، plasma enzymes activity، performance in broilers with pulmonary hypertension syndrome (PHS) during 4 weeks. A total of 160 male broilers randomly were divided in 2 groups of 4 replicates and 20 chicks for any replicate. At day 14، temperature was reduced to amplify the incidence of Pulmonary Hypertension Syndrome. Two treatment groups were: 1: Control group and 2: Control group with 100g glutamine/ Kg feed. Average BW gain، average feed intake and average feed conversion ratio were measured weekly from week 3. Mortality was inspected to determine cause of death and diagnose of heart failure. Hematological، biochemical and pathological tests were used; total red blood cell (RBC)، hemoglobin (HGB)، hematocrit (HCT)، release of alanine transaminase (ALT)، aspartate transaminase (AST)، lactate dehydrogenase (LDH). At end of the experiment (wk 6)، 2 chicks from each replicate were randomly selected and slaughtered. The heart was removed; the right ventricle was dissected away from the left ventricle and septum then ratio of right ventricle weight to total ventricle weight (RV/TV) calculated too. The results indicated that glutamine significantly، (P≤0. 05)، improved feed conversion ratio at week 5 and total experiment period. None of RBC، Hct and Hgb was not affected by glutamine. Glutamine at day 42، significantly reduced Plasma enzyme actives ALT and AST، nonetheless، LDH activity was not affected by glutamine supplementation. It is also، glutamine significantly reduced RV/TV and mortality compared to Control.