Quantitative and qualitative scintigraphic measurement of Renal function in Persian cat using 99mTechnetium ethylenedicysteine and 99mTechnetium diethylenetriaminepentaacetic

To consider the use of renal scintigraphic evaluation of kidney function in Persian cat and make a comparison between 99mTechnetium ethylenedicysteine and 9 mTechnetium diethylenetriaminepentaacetic in renal scintigraphy.Design: Descriptive studyAnimals: 6 male healthy adult Persian cats - no clinical sign of renal disorders and prior to presentation.Procedure: The scintigraphy of right and left kidney using Gamma camera (Piker Model) and 9 mTc-EC and 99mTc-DTPA as radiopharmaceuticals. Peak activity percentage (% PA), peak time (Tmax), half emptying-time (T1/2), total and individual GFR and flow and function time activity curves (TACs) are the determined parameters in this evaluation. % PA, Tmax and T1/2 in left and right kidney for 99mTc-EC and 99mTc-DTPA respectively, were 49/86 %, 50/1 %, 11/3 min, 11/5 min, 4/4 min, 4/6 min and 51/27 %, 49/05 %, 7/7 min, 8/3 min, 3 min, 3/43 min. Moreover the quantities of total and individual GFR for left and right kidney measured by 99mTc DTPA measured by modified Gates technique respectively, were 125/69 ml/min, 64/42ml/min 51/26 %), 61/24ml/min (48/73 %) and were in normal range defined by Gates technique.Conclusion and Clinical Relevance: normal indices obtained for listed parameters and total and individual GFR quantities can play a major role in order to diagnose kidney disorder or function deterioration and can be a background and specialized knowledge conducive to future studies. Also comparison of two radiopharmaceuticals 99mTc-EC and 99mTc-DTPA showed that 99mTc DTPA scintigraphy has the superiority to assess the quantities of total and individual GFR so we can use 99mTc-DTPA to evaluate Glomerular filtration rate in both kidneys.