Effect of 8 Weeks of Endurance Training on Rest Levels and Response of Visfatin and Insulin Resistance Index to Acute Endurance Exercise in Diabetic Rats

The aim of this study was to investigate the effect of eight weeks of endurance training on rest levels and the response of vistafin and insulin resistance index to acute endurance exercise in diabetic rats. 60 diabetic wistar rats (8-10 months old, 150-170 gr.) were randomly divided into sedentary diabetic control (n=29) and trained diabetic groups (n=31). Diabetes was induced by single intravenous injection of streptozotocin (STZ; 50 mg/kg BW). The trained rats performed incremental endurance training for 8 weeks, 5 times/week. After 8 weeks, all rats participated in one single bout of acute endurance exercise consisting of running on a treadmill with the velocity of 20m/min, 30 min, %5 inflation. Blood samples were collected before and immediately after the training. The research variables included visfatin, insulin, glucose and the resistance to insulin index. To specify the effect of endurance training on blood factors, the pair t test was used. Additionally, the effect of training on the response of the indexes to acute endurance exercise was determined by analysis of variance with repeated measures (2X2). Results showed that visfatin rest levels did not decrease after endurance training (p=0.895, t=0.037) while these levels significantly reduced (p < 0.001) in response to a bout of acute exercise. Insulin resistance was decreased after 8 weeks endurance training and in response to acute endurance exercise. Also, resistance to insulin significantly reduced after eight weeks (t=0.145, p=0.001). This variable significantly changed in response to acute endurance exercise. Generally, visfatin plasma levels reduced in response to acute exercise in diabetic rats.