Effect of bisphenol A exposure on plasma sex steroid hormone levels in male Yellowfin Seabream (Acanthopagrus latus)

Bisphenol A (BPA)، an industrially chemical compound، is abundantly used as a primary raw material for production of polycarbonate plastics، epoxy resins and many industrial productions. To show the effect of BPA on plasma steroid hormone variations، male Yellowfin Seabream were subjected to this compound. Fish were intraperitonealy injected by dissolved BPA in coconut oil (10، 50، 100 and 150 µg/g-1 week-1) of over 2weeks. Plasma samples were collected on days 0، 7 and 14. Plasma levels of steroid hormones (testosterone and 17b-estradiol) were determined by radioimmunoassay. Plasma levels of 17b-estradiol hormone in BPA treated fish was significantly increased in a dose dependent manner، after 7 and 14 days of exposure (p<0. 05). Plasma levels of testosterone showed decrease in response to different concentrations of BPA. However this decrease in testosterone levels was significant only in response to 100 and 150 micrograms per gram of BPA. It can be concluded that short term exposure of Yellowfin Seabream (Acanthopagrus latus) to BPA can make destructive effects in reproductive system.