Sciatic Nerve Graft and Repair with Fibrin Glue and Suplemental Suture (Animal Study in Rat)

Fibrin glue can be used for nerve repair. This study is to evaluate the repair of severed sciatic nerve in rats done by fibrin glue، comparing with an untreated group. In an interventional case series study، 18 Sprague rats had their sciatic nerve cut in the intervertebral canal. Fourteen rats were repaired by graft-repairing of nerve using fibrin glue and single suture. Four rats were left untreated as controls. The recovery of motor function was assessed after 4 months. Lower extremity muscle atrophy and absence of motor function recovery was observed in the untreated rats. Full functional recovery in lower limbs was observed in the 12 treated rats، while 2 rats walked with limp. The cut sciatic nerve repair in rat''s spinal canal، using fibrin glue and a microsurgical suture would result in good function motor recovery of lower extremity.