Plasma progranulin and relaxin levels in PCOS women with normal BMI compared to control healthy subjects

Poly Cystic Ovary Syndrome (PCOS) is the most commonly encountered endocrine gland disease affecting 5-10 present of women at their reproductive age. This syndrome is associated with type 2 diabetes، dyslipidemia، and obesity. Progranulin and relaxin are adipokins that are related with carbohydrate and lipid metabolism. Due to limited data about progranulin and relaxin plasma levels´ in women with PCOS and normal BMI، this study was conducted. This study is a cross-sectional. During the study 39 women with PCOS and BMI< 25 on the basis of Rotterdam criteria were chosen as the patient group and 38 healthy women were selected as the control group. The concentration of progranulin and relaxin were measured by ELISA technique. The difference in Plasma concentration of progranulin and relaxin، and also some of the biochemical parameters in the patient group versus to the control group was not significant، but there was significant difference in the concentrations of VLDL، triglyceride (p=0. 046)، insulin (p=0. 016)، HOMA-IR (p=0. 015)، testosterone (p=0. 01)، and DHEAS (p=0. 034) in the patients group compared to the control group. In this study، the difference in Plasma concentration of progranulin and relaxin in the patient group compared to the control group was not significant. It could be inferred that lack of change in plasma level of progranulin and relaxin in women with PCOS is related to BMI<25 and FBS<110. Moreoverestosterones، insulin، DHEAS and HOMA-IR changes could be better predictors of PCOS and its associated diabetes.