The Comparative Effect of Antioxidant Activity of Copper, Vitamin E and Vitamin C to Prevention of Molybdenum Toxicosis in Rabbit

Oxidative stress is defined as an imbalance between oxidants and reluctant in the individual or its cells. The aim of this study was to compare the effects of antioxidant vitamins E and C in prevention of the toxicity of copper and molybdenum in rabbits. In this experimental study، 25 adult rabbits were randomly divided into 5 groups. The first group (control group) received no medication The second group received 80 mg/Kg/day sodium molybdate orally until symptoms of toxicity، the third group received 4 mg/kg of copper sulfate orally with sodium molybdate، Group IV 150 mg/kg of vitamin E with sodium molybdate orally، and group V 20 mg/kg orally received vitamin C with sodium molybdate. Using the total antioxidant capacity parameters، malondialdehyde and ceruloplasmin levels in rabbit’s serum parameters levels of oxidative stress and antioxidant defense were obtained after a 35-day trial. The obtained data was analyzed using ANOVA and Turkey''s test. The results of the present study indicated that molybdenum induced alopecia and depigmentation and molybdenum as a stress factor increased levels of malondialdehyde. So that the amount of malondialdehyde from 1. 285 in the control group to 1. 849 µM/L Molybdenum increased significantly. Although this indexes in the groups receiving vitamin E and C decreased significantly from 0. 375 to 0. 426 µM/L respectively. However، the total antioxidant capacity in any of the groups compared with the control group showed no change. Molybdenum toxicity is involved in the pathogenesis of oxidative stress and antioxidant agents of vitamins E and C can reduce its toxic effects.