Serum Adiponectin Level and Lipid Profile

Adiponectin، hormone secreted by adipose tissue، which is inversely associated with body fat mass. This hormone has anti-inflammatory and anti-atherogenic properties. Concentration of adiponectin reduces in metabolic syndrome، cardiovascular diseases and dyslipidemia. Thus، the aim of the present study was to review the recent evidences about association between serum adiponectin level and lipid profile. PubMed was searched from 2002 to October 2011، by using the following key words: dyslipidemia، lipid profile، triglyceride، high or low density lipoprotein cholesterol (HDL-C or LDL-C)، total cholesterol and adiponectin. Twenty-five articles were recruited in this review. Serum adiponectin level positively regulated plasma HDL-C concentration. Adiponectin was inversely significantly associated with serum triglyceride. Plasma adiponectin had a potential inverse correlation with very low and low density lipoprotein cholesterol (VLDL-C and LDL-C). Adiponectin R2 receptors had an important role on metabolism of VLDL-C and TG. Adiponectin was reduced in abnormalities of lipid profile and had an important role on metabolism of plasma lipids.