Comparison of the effects of growth hormone on acylated ghrelin and following acute intermittent exercise in two levels of obesity

The prevalence of obesity has risen enormously over the past few decad-es. Both food intake (Appetite) and energy expenditure can influence body weight. Acylated ghrelin enhances appetite، and its plasma level is suppressed by growth horm-one. The present study، examines the effects of an intermittent exercise with progress-ive intensities on acylated ghrelin، appetite، and growth hormone in inactive male students with two levels of obesity. Eleven inactive males were allocated into two groups on the basis of their body mass index (BMI). Six subjects in group one، BMI= 31. 18±0. 92 kg/m2، and five subjects in group two، BMI= 36. 94±2. 25 kg/m2، ran on the treadmill with progressive intensities of 50، 60، 70 and 80% of VO2max for 10، 10، 5، and 2 min respectively. Blood samples were collected before the exercise (as the resting values)، after each workload (during the exercise)، and at 30، 60، and 120 min (during recovery). Plasma acylated ghrelin concentrations and hunger ratings in two groups were decreased and remained significantly lower than resting values (P=0. 008 and P=0. 002 respectively) at the end of the trial and there was no significant differences between groups. Growth hormone levels in two groups were increased and remained significant-ly higher than resting values (groups one P=0. 012، group two P=0. 005) at the end of the trial and there was no significant differences between groups. In addition، there were no significant differences between area under the curves (AUC) values over total periods for acylated ghrelin، hunger ratings، and growth hormone in two groups. These findings indicate that individuals with two levels of obesity have the same response to the different intensities of treadmill running and two hours thereafter during recovery period، which can be considered for designing a more effective weighting loss training program.