Physical Activity and Concentration of Serum Glycosylated Hemoglobin

With increasing physical activity and energy expenditure based on various intensities and durations of exercise training in diabetic and non-diabetic individuals، the morbidity and complications of diabetes are decreased and hyperglycemia is desirably controlled. Is there a correlation between estimated maximum oxygen consumption (VO2max) and concentration of serum glycosylated hemoglobin (HbA1c) in active، sedentary and coronary artery disease (CAD) men? What is the possible range of the correlations? The aim of this cross-sectional study was to determine and compare the correlations between VO2max and concentration of HbA1c. The participant subjects comprised of three groups of active، sedentary and CAD men (40-55years) who were randomly and voluntarily selected for the study. VO2 max was estimated based on non-exercise prediction equation. Fasting blood levels of HbA1c were measured by an enzymatic immunoassay method. Correlations between estimated VO2max and HbA1c were determined via Spearman rank correlation coefficients. The statistical tests، T-Fisher and Z-Fisher، were applied for signification and comparison of them at the significant level of p ≤ 0. 05. The amount of analyzed parameters were as follow: VO2max (active: 39. 039 ± 2. 563، sedentary: 32. 647 ± 3. 056 and CAD: 30. 375 ± 4. 275 mL. Kg-1. min-1)، fasting blood HbA1c (active: 4. 266 ± 0. 365، sedentary: 4. 733 ± 1. 370 and CAD: 5. 253 ± 1. 321 mg/dl). The correlation coefficient between VO2max and HbA1c was significant in CAD men (rs(13) = - 0. 538٭، p = 0. 039) but were not significant in active (rs(13) = - 0. 291، p = 0. 292) and sedentary (rs(13) = - 0. 338، p = 0. 217) men. Discussion & According to the above results، it could be concluded that the physical activity has no any desirable effect on HbA1c and HbA1c is resistant to exercise training.