Relation of menopausal with total Antioxidant capacity, Super Oxide dismutase and catalase activity enzymes

Regarding estrogen role in free radical scavenging، secretion cessation of estrogen in menopause is considered as the source of ROS increase. due to deficiency of estrogen، antioxidant defence system seems to be affected in this phase. The aim of this study was Assay of total antioxidant capacity and superoxide dismutase and catalase activities in menopausal women. This case-control study was performed on 75 postmenopausal women as a case group and 74 volunteer premenopausal women as a control was performed. Serum enzyme activity of catalase، superoxide dismutase and total antioxidant capacity was measured in the fasting state. The amount of total antioxidant capacity in postmenopausal (11. 4±4. 4 mM Trolox) compared to the control group (10. 3±1. 2 mM Trolox) were significantly decreased (p<0. 05). The activity of superoxide dismutase in postmenopausal (1. 92±0. 14 Unit/mg-protein) compared to the control group (2. 07±0. 09 Unit/mg-protein) were significantly decreased (p<0. 05). The obtained data showed that total antioxidant capacity and activity of superoxide dismutase enzymes decrease in the postmenopausal women. Increasing of Oxidative stress cause probably result in reduction of total antioxidant capacity and superoxide dismutase enzymes activity.