Precocious Puberty with Hypothalamic Hamartoma: A Case Report

Hypothalamic hamartoma is a rare cause of central precocious puberty in female children. Hamartoma is a malformation composed of ectopic gonadotropin-releasing hormone (GnRh) neurons which secrete pulsatile gonadotropine releasing hormone. Case Report: We present a case of a 1. 5-years-old female baby who presented with precocious puberty associated with hypothalamic hamartoma. Serum concentrations of follicle-stimulating hormone (FSH)، luteinizing hormone (LH) and estradiol were elevated. She was treated with GnRh agonist and gamma-knife surgery. The size of breast and pubic hair returned to normal after 6 months of therapy. This case report emphasized how this condition should be evaluated and how the girl was managed.