Effects of Oligofructose-enriched inulin prebiotic supplementation on the lipid profile and inflammation in patients with type 2 patients: A randomized controlled trial

Considering the high prevalence of diabetes and developing cardiovascular diseases via dyslipidemia and inflammation in type 2 diabetic patients، the aim of the present study was to investigate the effects of Oligofructose-enriched inulin on serum lipid concentrations and inflammation in type2 diabetic patients. In this clinical trial، 52 patients with type 2 diabetes were assigned to one of two groups. Experimental group (n=27) received 10g/d oligofructose-enriched inulin and control group (n=25) received 10 g/d maltodextrin for 8 weeks. Dietary intakes، anthropometric measurements، hs-CRP and serum lipids concentrations were measured at the baseline and at the end of the study. Data were analyzed using SPSS software (verision11. 5). Paired، independent t-test and ANCOVA were used to compare comparison of quantitative variables. At the end of study we observed significant decrease in total cholesterol (28. 00 mg/dL، 14. 10%)، LDL-c (22. 00 mg/dL، 21. 7%)، TC/HDL-c ratio (-0. 73، 20. 7%) and LDL-c/HDL-c ratio (-0. 55، 27. 5%) in oligofructose-enriched inulin compared with the maltodextrin group (p<0. 05). Changes in concentrations of triglycerides and high-density lipoprotein were not significant in oligofructose-enriched inulin compared to maltodextrin group. Oligofructose-enriched inulin supplementation with improving in inflammtion and lipid profile help in management of type 2 diabetes and its complications.