Effect of levamisole on cholesterol, triglycerol and lipoprotein level of common carp (Cyprinus carpio L.) blood serum

Levamisole is one of the anti-parasitic drugs that widely used in veterinary and aquatic animal medicine. Previous investigation showed that levamisole has some stimulatory effect on immunity and liver metabolism. In this investigation effect of levamisole on cholesterol، triglycerol and lipoproteins as metabolic activity indicator has been studied. For this purpose 120 common carp randomly divided to 4 groups. Three groups were fed with food contain three levamisole concentrations (100، 500، 1000 mg/kg levamisole). The 30 other fish were fed with same food but without levamisole. After 30 days blood were collected and cholesterol triglycerol level and lipoproteins were measured. Result showed that in Triglyceride level in 500 and 1000 mg/kg group was significantly higher than the 100 mg/kg and the control group (p<0. 05). But the cholesterol levels in experimental groups were significantly lower than the control. High-density lipoproteins (HDL) level was decreased in all experimental groups in comparison with the control group (p<0. 05). However، the low-density lipoproteins (LDL) and the very-low-density lipoproteins (VLDL) levels were increased in all experimental groups in comparison with the control (p<0. 05). This investigation showed that levamisole had mark effect on cholesterol and triglycerol level of serum in common carps، however the changes were laid in approximate levels of normal ranges for the particular factor.