Effect of Exposure to Chronic Heterogeneous Sequential Stress during Prenatal on Formalin-Induced Nociceptive Behaviour in Adult Offspring in Rats
There are different kinds of stress on mothers during prenatal period. The present study investigated the effects of exposure to chronic heterogeneous sequential stress during prenatal period on formalin-induced nociceptive behavior in adult offspring.
In the present study، animals were divided in stressed and non-stressed groups and their offspring divided in male and female groups. Heterogeneous sequential stress including food deprivation، water deprivation، restraint، restraint at room temperature، restraint at 4◦C، forced swimming and social isolation were applied during days 9 to 19 of gestation. Formalin test as chemical model and hot-plate as thermal pain model were used in rats.
Chronic heterogeneous sequential stress increased the nociceptive behaviors in male rats in first part and in female rats in second part of phase 2 of formalin test compared with controls.
The result of this study showed that chronic heterogeneous sequential stress in rats increased the nociceptive behaviours in second phase of formalin test in a gender-dependent order; which suggested chronic heterogeneous sequential stress may be useful in evaluating the basic mechanism of exposure to chronic heterogeneous sequential stress during prenatal period on in adult offspring.
Journal Of Isfahan Medical School, Volume:31 Issue: 256, 2013
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!