Investigation of Antiinflammatory and Antinociceptive effects of hydroalcholic extract of Nepeta menthoides aerial parts in male mouse

The application of herbal plants instead of synthetic drugs is increasing in recent years because of their lower side-effects and high varieties of efficient components. The study of antinociceptive and anti-inflammatory effects of hydroalcoholic extract of Nepeta menthoides seems to be necessary due to the existence of its components.

This study has been done on 224 NMRI male mice of 20-25 g in weight.. We used Xylene-induced ear edema and Formalin Test for demonstrating its anti-inflammatory and antinociceptive effects.

The hydroalcholic extract hasn’t toxic effect. This study shows that Nepeta menthoides aerial parts has anti-inflammatory effect at all doses، particularly at dose of 2800 mg/kg and decreased nociception meaningfully in chronic phase. Dose of 2800 mg/kg had the most antinociceptive effect in chronic phase. Meanwhile، in immersion test، nociception decreased at dose of 1400 mg/kg significantly.

The hydroalcoholic extract of Nepeta menthoides has antinociceptive and anti-inflammatory effects. This effects may be from its Nepetalactone and 1،8 cineole components.