Protective effects of Eriobotrya Japonica flower Extracts against intraventricular 6-hydroxydopamine-induced lesion in male rats

Oxidative stress contributes to dopamine cell degeneration in Parkinson’s disease (PD). This study was performed with the aim of protective effects of Eriobotrya Japonica flower extract (EJFE) on intraventricular 6-hydroxydopamine-induced lesion in male rats. In this laboratory experimental study، Twenty seven rats were divided into three groups: control، Lesioned and extract treated Lesioned. Lesion induced with injection of 250 mg/kg of intraventricullar 6-hydroxydopamine (i. c. v. 6-OHDA). Lesioned and extract treated lesioned groups received Saline and extract (200 mg/kg) three times per 12 weeks intraperitoneally. Five days after i. c. v. 6-OHDA injection، Tyrosine hydroxylase and dopamine levels in the striatum were measured by ELISA method. Data was analyzed using one-way analysis of variance (ANOVA). Results show that Consume extract significantly prevention of decrease dopamine levels in Parkinson rats (p= 0. 001)، but tyrosine hydroxylase level don’t change in extract group (p= 0. 86). The results of this research showed that pre-treatment with hydroalcoholic extraction of Eriobotrya japonica increased protective against 6-OHDA lesion and maybe have protective role against Parkinson disease.