Association of the -11377 Adiponectin Gene Polymorphism with the Risk of Postmenopausal Breast Cancer

Breast cancer is the most common malignancy in women with a prevalence of 0. 15% in Iran. Adipokines produced by the adipose tissue have been studied in relation to the risk of breast cancer. Adiponectin is an adipocyte-secreted hormone. The inverse correlation between serum adiponectin levels and the risk of postmenopausal breast cancer has been recently documented. Genetic polymorphisms in the promoter region of the adiponectin gene are associated with the differences in adiponectin serum levels. The purpose of this study was to explore the relationship between -11377 G/C adiponectin gene polymorphism and the risk of postmenopausal breast cancer in Iranian patients. Blood samples of 100 females with postmenopausal breast cancer (age rang: 54. 8±10. 1) and 100 age- and sex-matched healthy individuals (age rang: 55. 3±6. 7) were collected. The genotypes were determined using a polymerase chain reaction (PCR) -restriction fragment length polymorphism (RFLP) method. In the dominant effect of the G allele (comparison between GG + GC vs. CC)، the GG+GC genotypes were associated with the risk of postmenopausal breast cancer (OR= 4. 6، %95CI= 1. 2-17. 6، P= 0. 03). It is concluded that the G allele may act as a dominant allele to increase the risk of postmenopausal breast cancer.