Effects of aerobic training on vascular endothelial activity (sICAM-1) & Insulin resistance index in sedentary diabetic)type II(men.

Diabetes and obesity are of the main cardiovascular risk factors. Improvement in cardiovascular function by physical activity has been attributed to exercise induced positive changes in metabolic abnormalities and risk factors that are associated with atherosclerosis. This study examined the effects of aerobic training on plasma Soluble Intercellular Adhesion Molecule -1 (sICAM-1) in sedentary Diabetic middle age men. Twenty- four diabetic male patients (age، 40-48 years) participated in the study. The subjects were randomly assigned to one of two groups: interval training group (n=12) and control group (n=12). Blood sample were taken in fasting state from all subjects. The Arobic training program included running training at an intensity corresponding to 60-80% of maximal heart rate، 3 day a week for 12 weeks. Intracellular adhesion molecule-1 and lipid profiles (cholesterol، TG، LDL-C and HDL-C) were measured. BMI، WHR and body fat percent also were assessed. There was significant decrease in sICAM-1 in the exercise group (P=0. 01، 16. 1%). The insulin level and HOMA-IR decrease significantly (P≤0. 05). In addition، plasma levels of Triglyceride، cholesterol، HDL-C and LDL-C (P≤0. 05). changed significantly. Hence there was significant relationship between ∆sICAM-1 and lipid profile and ∆Wight، ∆BMI & ∆HDL-C. aerobic training by mediating lipid profile and anthropometric indices، can decline inter cellular inflammatory agent in sedentary Diabetic middle age men.