Probiotic Therapy, What is the most Effective Method for Host Protection Against Enteric Pathogen
Author(s):
Abstract:
Background
Prevention of adverse microbial colonization is supposed to be the most important beneficial effect of the gut microflora..Objectives
The aims of the present study were to compare the effect of co-incubation, pre-incubation and supernatant of sixteen probiotic strains on prevention of enteroinvasive E. coli adhesion..Materials And Methods
Probiotic strains were added to Caco-2 cells followed by E. coli in pre-incubation assay. Tested strains and enteroinvasive E. coli were added to cell lines at the same time in co-incubation assay. Finally, enteroinvasive E. coli was treated with bacteria free supernatant of test strains then added to cell line in treatment with bacteria free supernatant assay..Results
This study showed that the most effective assays in prevention of pathogen adherence were treatment with bacteria free supernatant and pre-incubation respectively..Conclusions
The effect of probiotic bacteria by-products on pathogen exclusion may be of more importance in protecting the host. Therefore, gut colonization or at least persistent presence of probiotics may be helpful in infection prevention..Keywords:
Probiotics , Pathogen Exclusion , Co , Incubation , Pre , Incubation , Caco , 2 Cells
Language:
English
Published:
International Journal of Enteric Pathogens, Volume:1 Issue: 2, May 2013
Pages:
36 to 42
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