Application of Proteomics to Identify the Biomarkers of Glomerular Diseases

Glomerular Diseases affect the filtration function of nephrons. In many patients، kidney failure eventually leads to end-stage renal disease (ESRD). The causes of the glomerular diseases should be diagnosed to appropriately treat the disease. Although a renal biopsy determines definitive diagnosis of the cause of the disease، it is an invasive and potentially hazardous procedure. Urine testing for biomarkers could replace renal biopsy as a simple، safe، and accurate test that could be repeated to follow up progression of the disease and monitor response to therapy. In recent years، in order to understand the mechanisms involved in glomerular disease، kidney injury and to distinct between them، notable proteomics studies have been done. It seems that by improvement of proteomic techniques in future، better results will be achieved. This article discusses this issue in detail.