Formulation and Evaluation of Orally Disintegrating Tablets of Captopril Using Natural Super Disintegrants

Difficulty in swallowing (dysphagia) is common among all age groups, especially in elderly and children. Orally Disintegrating tablets constitute an innovative dosage form that overcomes the problems of swallowing and provides a quicksetof action. The purpose of this study was to formulate and evaluate an orally Disintegrating Tablet (ODT) containing captopril while using croscarmellose sodium, crospovidone and two natural superdisintegrants: karaya gum and natural agar. For the preliminary study 12 batches were prepared. A 32 full factorial design was applied to optimize the formulation and 9 batches were prepared and evaluated. From the preliminary study it was found that ODTs containing karaya gum showed a better disintegration time and hence it was considered for further studies.