Evaluating the Effect of Intravenous Haloperidol and Midazolam on Postoperative Nausea and Vomiting after Strabismus Surgery

Usage of midazolam and haloperidol for prevention of postoperative nausea and vomiting has been considered before. Purpose of this study was to evaluate the anti-emetic effect of combination of haloperidol with midazolam on postoperative nausea and vomiting in patients underwent strabismus surgery. In this randomized, double-blind, placebo-controlled study, 90 patients with the age of 18-60 years underwent general anesthesia for strabismus surgery in Feiz hospital, Isfahan, Iran, were divided into 3 groups of 30. Group A received 0.05 mg/kg of midazolam, group B received 0.05 mg/kg of midazolam plus 0.05 mg/kg of haloperidol, and group C was the control group. The incidence of postoperative nausea and vomiting were evaluated in post-anesthesia care unit and ward. Making a comparison, the incidence of postoperative nausea and vomiting in group B was significantly lower than groups A and C (P < 0.05 for both). The lowest incidence of postoperative nausea and vomiting happened in group B, where the postoperative anti-emetic need was significantly lower than groups A and C (P < 0.05 for both). Administration of 0.05 mg/kg of haloperidol plus 0.05 mg/kg of midazolam reduces the postoperative nausea and vomiting more than midazolam alone in patients undergo strabismus surgery.