Comparison of Three Heparinization Methods of Hemodialysis Set on Coagulation Condition and Dialysis Efficacy in Patient Undergoing Hemodialysis

Nowadays Heparin is used in hemodialysis set for anticoagulation by different methods. Each of these methods will increase the rate of mortality by clot formation. This clinical trial study intended to investigate the effect of three heparinization methods of hemodialysis set on coagulation condition and dialysis efficacy.

Twenty five hemodialysis patients with bp normal PTT were selected randomly and underwent three methods of anticoagulation. In the first method after priming by 5000u heparin، 200cc normal saline was infused into hemodialysis set two times. In the second method، 2000u bolus and 1000u/hr were injected at the beginning of the fourth hour. In the third method، 2500u bolus and two hours later 2500u were injected. Clot formation was evaluated at the end of the hemodialysis session visually and the efficacy of dialysis and PTT were calculated by URR،KT/V formula. The study data were analyzed via SPSS using Wilcoxon tests.

The results revealed that clot formation in the first method was significantly higher than the second and third methods (p-value=0) and in the third method، it was also more than the second method (p-value=0). Moreover، the standard PTT in the first method was more than the second method (p-value=0). Dialysis efficacy in the second method was higher than the first method (p-value=0. 002).

The probability of clot formation in the second method of heparinization is less than the other methods. Dialysis efficacy in this method is also higher than the other methods. Thus، the second method is recommended.