Immunohistochemical Comparison of CD105 and Snail2 Expression in Oral Squamous Cell Carcinoma and Dysplastic Epithelium

CD105 is a cell membrane hemodymeric glycoprotein and the basic marker of neovascularization. Snail2 is a transcription factor and results in impaired epithelial adhesion. The purpose of this study was to compare the expression of CD105 and Snail2 in dysplastic epithelium and oral squamous cell carcinoma (SCC). In this descriptive - analytical study، a total of 40 paraffinized blocks of SCC and dysplastic epithelium were subjected to immunohistochemical staining with CD105 and Snail2. Expression of CD105 and snail2 and their correlation with other and with clinicopathological parameters were evaluated. The data were analyzed by t، Man-Whitney، ANOVA tests. The mean micro-vessel density with CD105 in SCC and dysplasia were 11. 73±5. 828 and 5±1. 892 respectively (P<0. 001). The mean micro vessel density in intra tumoral area was 7. 75±4. 329 and in peri tumoral area was 15. 7±7. 26 (P<0. 001). Average density of Snail2 in SCC was higher than that of dysplasia (P<0. 001). There was no significant relationship between age، sex، tumor location and differentiation grade، and CD105 marker but a positive correlation existed between Snail2 and differentiation grade of SCC (P=0. 007). In transformation of dysplasia to squamous cell carcinoma with increase in the expression of CD105، increased expression of Snail2 was observed. (P<0. 001، r=0. 76) The results of the present study showed the role of CD105 and Snail2 in the incidence of carcinogenesis. The direct relationship in the expression of CD105 and Snail2 supports the role of them in progression of the premalignant lesion to malignancy. Snail2 can be an effective factor in progression of oral carcinogenesis.