THE EFFECT OF 6 WEEKS ENDURANCE TRAINING ON GENE EXPRESSION OF NERVE GROWTH FACTOR IN SENSORY SPINAL CORD OF RATS WITH DIABETIC NEUROPATHY
Author(s):
Abstract:
Background
Diabetic neuropathy is one of the most common complications of diabetes mellitus، which is associated with a decrease in the synthesis and transport of neurotrophins. The aim of present study was to investigate the effect of endurance training on gene expression of nerve growth factor (NGF) in the sensory spinal cord of rats with diabetic neuropathy. Methods
Twenty eight adult male Wistar rats in the body mass range of 326. 3±8. 4 gr، randomly assigned in to four groups: diabetic control، diabetic training، healthy control and healthy training. For inducing diabetic neuropathy، after twelve hours of food deprivation، intraperitoneal injection of STZ solution (45 mg/Kg) method was used. Two weeks after STZ injection، the endurance training protocol was performed for six weeks and Twenty four hours after the last training session، rats were sacrificed. Gene expression of NGF in rat spinal sensory segments were measured with Real time technique. In order to determine the significant differences between groups and Interaction independent variables two way anova and LSD post hoc test were used. Results
Endurance training، resulted in a significant increase in gene expression of NGF in the rats. Also، in compare with diabetic control، training led to significant decrease in blood glucose levels in diabetic training group. Conclusion
Increased physical activity and exercise can strongly affect pathological factors associated with diabetic neuropathy by increasing nerve growth factor. It is recommended that for prevention of neurological complications and treatment of diseases associated with diabets exercise training could be used as a non-pharmachological treatment.Keywords:
Language:
Persian
Published:
Iranian Journal of Diabetes and Lipid Disorders, Volume:13 Issue: 3, 2014
Pages:
263 to 271
magiran.com/p1288023
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!