Association Study of IL16Gene Polymorphism with the Risk of Sporadic Alzheimer's Disease
Author(s):
Abstract:
Background
Interleukin-16(IL16) is an important regulator of T cell activation and was reported to act as achemo-attractant agent. There are evidences that IL16 can control the neuroinflammatory processes in Alzheimer’s disease (AD). This study was performed to show whether the IL-16 genepolymorphism, rs11556218 is associated with the risk of sporadic AD in Iranian population. Materials And Methods
Totally, 148 AD patients and 137non-dementia controls were recruited in this case-control study. Genotyping of rs11556218 T/Gpolymorphism was performed by PCR-RFLP method using the NdeI restriction enzyme. Results
Statistical analysis of rs11556218 genotypes showed a protective effect against AD in the heterozygote genotype (p=0.001, OR=0.16(0.1-0.28)). Frequency of rs11556218 allele T was higher in patients than controls(p=0.001, OR=0.32(0.21-0.49)). Conclusion
Our results indicate thatrs11556218 polymorphism has a protective role in the development of sporadic AD in Iranian population.Keywords:
Language:
Persian
Published:
Journal of Arak University of Medical Sciences, Volume:17 Issue: 7, 2014
Pages:
41 to 47
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