The effect of some flavonoids on paraoxonase-1 activity

Paraoxonase-1 is a calcium dependent enzyme which is related to HDL. Paraoxonase LDL plays an important role in prevention of atherosclerotic lesions by having preventing potential. Different antioxidants such as flavonoids affect serum paraoxonase activity. In the current study, the aim was to investigate the effect of some flavonoids on serum paraoxonase activity.

In this animal experimental study, 45 Wistar rats in 9 groups of 5 animals received flavonoids by gavage feeding as follows: Group 1 as control group received 1 ml water daily and ethanol with concentration 0.25. Group 2-5 and 6-9 was fed with 7.5 and 15 mg/kg for per kilogram of body weight (BW) of the one of myricetin, quercetin, kaempferol and galangin flavonoids along with 1 ml ethanol 25%. The mean of changes in enzyme activities due to performed intervention between groups was compared using one-way ANOVA.

There were significant differences between PON-1 enzyme activity changes before and after intervention in both dosages 7.5 and 15 mg/kg body weight (P=0.04). There were significant differences in increasing concentration between PON-1 enzyme activity changes before and after intervention (Gavage for 4 types of flavonoids) compared to control groups (P≤0.009), but there was not any significant difference between PON-1 enzyme activity changes used two dosages of flavonoids (P>0.05)

In this study, it was shown that all of the flavonoids increased paraoxonase activity. Probably, the potential of flavonoids in increasing serum paraoxonase activity is related to the number and location of hydroxyl groups on these compounds.