The preventative role of MgO nanoparticles in amnesia induced by morphine in male mouse

Consumption of opioid agonists such as morphine before and after training distruct the memory. It has been shown that some magnesium supplements improve various forms of memory but influx limitation of the ion via the blood brain barrier has limited its use. Mineral nano particles such as magnesium oxide nano particles (nano MgO) with unique physiochemical properties، can easily pass across biological barriers but their effects on memory and amnesia are not clear. In this study effect of magnesium oxide nanoparticles on morphine induced amnesia has was been investigated. In this study، the mice in the weight range 25to 30g were used in 12 groups consisted: control، receiving morphine (5 and 10 mg/kg)، receiving nano MgO (1، 2. 5، 5، 10 mg/kg، IP) and interaction groups of morphine and nano MgO. The Step-down apparatus was used for evaluating the passive avoidance memory. The results showed that morphine administration after training in dose of 5 mg/kg made significant amnesia. MgO nanoparticles in doses of 2. 5، 5، 10mg/kg after training improved passive avoidance memory but had no effect on locomotor activity. However، mgo in these doses inhibited morphine induced amnesia. It seems that MgO nanoparticles prevent the mechanisms of morphine induced amnesia by passing through blood brain barrier and involving in memory pathways.