Serum biochemical indices changes following clinical propofol anesthesia in dogs

Serum level of renal indices (Creatinine and Urea), Hepatic enzymes (AST and ALT), Lipid profile (Cholesterol, Triglyceride, HDL, LDL), Glucose, Pancreatic enzymes (Lipase and Amylase) and Serum proteins (Total protein and Albumin) was measured in propofol total intravenous anesthesia.Six clinical healthy dogs (weighed 19.33 ± 7.44 kg) were selected. Anesthesia induced by 8 mg/kg from a 1% propofol solution and maintained by 0.3 mg/kg/min continuous infusion of propofol. A control serum sample was taken 24 hours before anesthesia and serial samples were taken on immediately before anesthesia, minutes 2, 10, 30 and 60 during anesthesia and hours 2, 6, 12, 24, 48 and 72 after anesthesia.Triglyceride level (246.16±87.96 mg/dl), cholesterol (315.5 ± 120.39 mg/dl), LDL (140.66 ± 94.23 mg/dl) increased significantly and ALT serum activity (28.16 ± 12.98 U/L) reduced significantly in comparison to zero time. No significant changes recorded in other parameters. Significant changes in serum lipid profile recorded as the main finding of the study that should be considered in sensitive animals.