Effect of 6-week interval training on the levels of lung HIF-1α in the maturing rat

The purpose of this study was to investigate the effects of 6-week Incremental Interval Training (IIT) on the levels of lung HIF-1α in the maturing rat. In this study، to assess the effect of two period IIT on lung HIF-1α protein، 30 Newborn three-week old male Wistar rats (68±9 g) after one week familiarization were randomly divided into basic، IIT and control groups. Interval training program for IIT group was performed with 10 reps 1-minute and 2-minute active rest for 6 weeks. Measurement of HIF-1α was performed by ELISA kits. The results of this study showed that IIT significantly Decreased body weight and lung weight of rats were 17/8 and 42/02 percent respectively as compared with the control group. Also significantly increased (P<0. 001) observed in levels of HIF-1α between IIT group in comparison with baseline and the control group. Seems that increase in lung HIF-1α، followed by IIT، causing the pathophysiology of the lung parenchyma and thereby a negative effect on the amount of rat ventilation. Meanwhile clarify the results and the reasons for its needed more research، particularly on human samples.