Teratogenic and cytotoxic effects of Salen, A current ligand in vanadium complexes

Metal salen complexes have been widely studied as potentially pharmaceutical substances with antioxidant and anti cancer effects. In this investigation the salen ligand was synthesized and injected in the air sac of the eggs. The liver and fibroblast cell cultures were treated by the compound and the proportion of the live cells was recorded. The survival fraction of the embryos was 23. 5% in the uppermost concentration of the compound and the LD50 was 91. 8 μM/egg. The morphological studies showed clubfoot، the abnormality of beak and ectopic viscera، and the skeletal staining showed the deletion and unosification of the caudal vertebrates، the brevity and the bending of tibia. The compound inhibited the growth of liver and fibroblast cells with the IC50 of 1159. 3 and 964. 7 μM، respectively. The treated cells were round، the inter-cellular connection became loose، the proliferation was inhibited، and the granules in the cytoplasm were increased. The compound significantly affected the proliferative cells compared with the cells were arrested in growth.