Effects of Achillea millefolium aqueous extract in a Parkinsons diaease model induced by intra-cerebral-ventricular injection of 6-hydroxydopamine in male rats

Oxidative stresses have some role in neuronal pathogenesis in Substantia nigra and induction of Parkinson's disease. It has been reported that Achillea millefolium has antioxidant and nuoropropective effects. In this study, we investigated the effects of Aqueous extract of Achillea millefolium in a Parkinson’s diseases model induced by ICV injection of 6-hydroxydopamin in male rats. In this experimental study, 60 male rats were allocated into 6 groups including Control, Parkinson’s and Parkinson’s groups which treated by different doses of extract. Parkinson’s was induced by i.c.v injection of 6-OHDA. Aqueous extract of Achillea millefolium (1.4 and 2.8 mg/kg) was gavaged by two ways including repeated gavage (14 days before and for 14 days after 6-OHDA injection) and acute gavage (once in day 13 after 6-OHDA injection). Parkinson’s was evaluated using Rotarod and Wire grasping tests on day 14 after 6-OHDA injection. The result of this study demonstrated that repeated gavage of Achillea millefolium extract improved motility and muscle tone following administration of 6-OHDA in rats (p<0.05). The results of this study demonstrated that chronic administration of Achillea millefolium extract may improve motility and muscle tone in Parkinson’s model in male rats.