The Effect of Oral Coriander Seed Extracts on Lipids, Blood Glucose, and Oxidative Stress Indicators in Streptozotocin-induced Diabetic Rats

Coriandrum Sativum seeds are used as a traditional drug for the treatment of high-cholesterol and diabetic patients. This study aimed to determine the effect of oral administration of coriander seeds extract on the levels of blood glucose, lipid profile, and oxidative stress in experimental diabetic rats. In this experimental study, four groups of 15 male rats were divided into groups of normal control, normal treated with coriander seeds extract, diabetic, and diabetic treated with coriander seeds extract. Blood glucose higher than 300mg/dl was considered as an indicator of diabetes. Oxidative stress indicators, including superoxide dismutase, glutathione peroxidase, malondialdehyde, catalase and lipid parameters, including triglycerides, total cholesterol, HDL, and LDL, blood sugar, and weight of rats during the experiments, were measured. Data were analyzed using one-way ANOVA, repeated-measures ANOVA, and Duncan's test. The significance level was considered p<0.05. In this investigation, the serum levels of glucose, lipid profile (p<0.001) and oxidative stress level were significantly affected by oral consumption of coriander seeds extract. No significant differences were observed between the normal rats fed by coriander seeds extract and treated diabetic rats for catalase. There was no significantly difference between treatment groups and control and diabetic groups for catalase. Treatment of diabetic rates with coriander seeds extract improved all oxidative stress indicators, compared to non-treated diabetic rats. Based on the results of this study, oral administration of coriander seeds extract in experimental diabetic male rats can improve disorders of blood sugar, lipid profile, and oxidative stress indicators.