Effect of different doses of PMSG and hCG on rate of matting and delivering in Wistar rats

Gonadotrophins are used for ovulation and number of oocytes in human and animals. The aim of this study was to determine the effects of different doses of gonadotrophin on mating behavior, delivery and number of pups in adult wistar rats. 60 female rats randomly divided to 5 groups (n=12 per group). Animals were treated with 75,100,150 and 300 IU/Kg each of PMSG and hCG by 48-50 h apart. Control group did not receive any drug. The successful mating of the females was assayed by examining vaginal smears between 07:00-09:00 am. The number of delivering mothers and infants was recorded on days 21-23, and defined as those successfully delivering pups. There were no differences finding among mating rates and delivery rates (p≤0.05). Our results showed that high doses of gonadotrophin improved the mating were whereas decreased the delivering rate. Mating rate showed significant changes between different groups but delivery rate and number of pups did not showed significant difference (p≤0.05). It could be concluded that high doses of PMSG and hCG, 150 IU/Kg could have inverse effects on reproductive status of Wistar rats.