Study of HMGB1 role in Cerebral Ischemia and the signaling pathway inhibitor drugs

Cerebral Ischemia is a neural disease which causes dying of a number of people every year. The disease usually exposures since stopping the blood pressure and also arresting of heart muscle. HMGB1 is a member of High Mobility Group superfamily proteins which all have a common DNA binding. HMGB1 is released as an extracellular signaling molecule and it binds to Toll like receptors at the cell membrane in the brain cells inflammations. Totally it leads to increase the cytokines and it also intensifies the inflammation. More inflammation can cause the brain cells apoptosis such as neurons and neuroglia cells. Rosamirinic acid، Tanshinone A and Tricin-7 Glucoside which were used for inhibition of HMGB1، they were studied using the Molegro Virtual Docker ans LiganScout softwares in this study. According to the scores، results showed that Tricin-7 Glucoside had better physical and spatial interactions with HMGB1 and TLR2 than others and also Tanshinone A had the best interaction with TLR4.