Preliminary Evidence-Based Pharmacotherapy of Mitoxantrone for Multiple Sclerosis in an Iranian Population
Author(s):
Abstract:
Background
Although mitoxantrone inhibits lipopolysaccharide induction of many immunological factors, but the mechanism of action somewhat remains to be more understood..Objectives
This preliminary study was designed to investigate the evidence-based mitoxantrone therapy results in patients with multiple sclerosis (MS)..Patients and Methods
This cross-sectional study on 71 patients with MS was carried out between 2010 and 2012, in an Iranian population. Demographic and pharmacological variables were recorded in d-Base. Statistical analyses were performed using SPSS for Windows..Results
The females/males sex ratio within the study population was 3.17: 1. The mean age of females was 32.2 years old (range 20 - 45 years) and the mean age of males was 52.7 years old (range 45 - 64 years). Out of the total population studied, 20% received both methylprednisolone (MP) pulse therapy and mitoxantrone on at least on one occasion. The mean frequency of dose received by each individual was two, with a range of one to five..Conclusions
To prevent the serious adverse effects of mitoxantrone, such as acute leukemia and secondary hematologic cancers, pharmacotherapy outcome, using disease modifying drugs, should focus on rate and severity of relapses within Iranian pateints with MS..Keywords:
Language:
English
Published:
Thrita, Volume:4 Issue: 13, Sep 2015
Page:
4
magiran.com/p1449821
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!