Prevalence of constitutive and inducible resistance to clindamycin in staphylococci isolates from Hajar and Kashani hospitals in Shahrekord, 2014

Clindamycin resistance in staphylococci is appeared in constitutive and inducible forms. Resistance to clindamycin in erythromycin resistant strains of these bacteria occasionally occurs that they cannot be detected by antibiogram routine procedures. This study was aimed to detect resistant inducible phenotypes to clindamycin in staphylococcal strains isolated from patients hospitalized in Shahrekord Hajar and Kashani hospitals. This descriptive-analytical study was performed on 200 strains of staphylococcus aureus and coagulase-negative staphylococci to methicillin. They were isolated from hospital clinical samples of patients hospitalized in Hajar and Kashani hospitals using disk diffusion method. Clindamycin resistance in erythromycin resistant strains was detected by developing a D- shape zone of sensitivity. Phenotype D from 200 isolates of methicillin-resistant staphylococci was detected in 6 isolates (3%) (1 staphylococcus aureus and 5 coagulase negative staphylococci isolates). Phenotype +D were observed in four isolates. 13 isolates had negative phenotype D. Inducible resistance test in staphylococcal strains is a suitable method for reorganization of the antibiotic resistance in these bacteria. It seems the performance of test D is necessary in erythromycin resistant strains. Implementing this test can present a better correct report about real sensitivities than these strains to clindamycin.