Prevalence of Human Leukocyte Antigen (HLA DQ2 and DQ8) in Celiac Disease in Patients with Irritable Bowel Syndrome

Celiac disease is a gastrointestinal disorder that genetic factors have a role on its pathogenesis. The aim of the present study was to determine HLA alleles encoding HLA DQ2 and HLA DQ8 in patients with celiac disease. This descriptive analytical study was conducted on 105 patients with IBS whom referred to the gastroenterology unit in Ardabil، Iran. The patients with positive celiac serology of IgA anti-tTG test were done an endoscopic duodenal biopsy. HLA DQ2 and DQ8 testings were performed on patients. Data were analyzed using descriptive statistics together with Mann-Whitney U and Fisher’s exact tests by SPSS-16. 14 patients were found positive for IgA antibodies against tTG. From these 14 patients 2 (14. 3%) were male and 12 (85. 71%) female. All of 14 patients (100% of case) had also abnormal intestinal pathology according to the modified Marsh classification and 10 patients had type IIIC. 11 patients had only HLA DQ2، 2 patients had only HLADQ8، and one patient had both HLADQ2 andDQ8. Most of patients had positive HLA D Q2. The present study emphasizes that HLA genotypes are an important background to CD development.