Serum Prostate Specific Antigen (PSA) Level in Acute Myocardial Infarction

Prostate Specific Antigen (PSA) is widely used as serum marker for prostate cancer. A relationship between PSA levels and Acute Myocardial Infarction (AMI) has been noticed during recent years. There is some discrepancy between results of different studies. Also no exclusive study was carried on evaluating the changes of PSA level after ST-segment Elevation Myocardial Infarction (STEMI). In vestigate the changes in serum PSA level in AMI (STEMI) patients. Twenty seven consecutive patients with diagnosis of AMI (STEMI) were selected. STEMI was diagnosed based on typical criteria: clinical features, Electrocardiogram, trans-thoracic Echocardiography, Creatine-Kinase MB (CK-MB) and troponin I (cTn-I) levels. All patients had tPSA and fPSA levels within normal range on admission day (day 0). The levels of tPSA, fPSA and f/tPSA ratio were determined on days 0,1, 2 and 3. cPSA was calculated as the difference between tPSA and fPSA. One way repeated ANOVA and logistic regression were used for analysis. The level of tPSA and cPSA were (0.985±0.755) and (0.783±0.585) on the day 0 and (1.14±0.875) and (0.936±0.736) on day 3 respectively. Serum tPSA and cPSA on the 3rd day were significantly more than the day 0 (p=0.032, p=0.047) respectively. fPSA did not show a significant difference. f/tPSA ratio showed a significant change over days(p=0.000), but the difference between the days was not significant. Logistic regression analysis showed a significant association between DM (OR=0.86; p=0.45) and creatinine (OR=8.7; p=0.01) with the change in tPSA on the 3rd day. As our results denoted a significant increase in tPSA and cPSA, but not fPSA in day 3 compared to day 0 we concluded that increase in tPSA may be due to elevation of cPSA. the changes in tPSA on the 3rd day was significantly associated with DM and Creatinine.