Effect of Multivitamin Complex Supplementation on Mood Disorders, Anxiety, and Depression in Elderlies

The association between some micronutrients deficiency and mood disorders has been demonstrated in several studies. But, the results of clinical trial regarding the effects of multivitamin complex on mood disorders are inconclusive. The aim of the present study was to investigate the effect of multivitamin complex supplementation on mood disorder, anxiety and depression in elderlies over 60 years old. In this clinical trial, 120 aged people with mild depression were randomly allocated to receive multivitamin complex tablet or placebo once daily with their meal for twelve weeks. At the beginning and end of the study, dietary intake, anthropometric indices and scores of depression, anxiety and mood disorders were assessed. This trial was completed by 114 elderlies after 12 weeks. The mean depression score was not different in two groups after intervention. The mean score of anxiety and mood disorders after intervention did not differ between groups. Similar results were obtained for weight and Body Mass Index. Significant enhancement of energy intake was illustrated by the measurement of participants’ dietary intake. The present study revealed that consuming a multivitamin complex in tablet form for 12 weeks had no effect on depression, anxiety and mood disorders in elderlies but can increase their appetite resulting in increase of their energy intake.