Hepatitis C virus infections in Non-Hodgkin lymphoma patients

The etiology of lymphoproliferative disorders arelargely unknown, a variety of genetic and environmental factors, under lyng diseases and viral infections have been proposed to be implicated to these lymphoproliferative cancers. viruses like Hepatitis type C virus)HCV(have so far been the most widely studied agent considered to be involved in the process of this malignant transformations such as Non-Hodgkin lymphoma)NHL(. In this research, for association between HCV infections and some types of lymphoproliferative malignancis and for HCV potential to infect human lymphocytes and some other hematopoietic cells, the prevalence of HCV infections in NHL patients was suggested. In this cohort and retrospective investigation, 70 EDTA treated blood samples were collected for 2 years from NHL patients and healthy control group respectively.HCV viremia by RT-PCR technique, and anti-HCV antibody by ELISA method,were tested for determination the HCV prevalence in NHL patients and control group. For determination the possible of HCV infections in this type B-cell lymphoma, all data were statistically analyzed. The prevalence of anti-HCV antibody was 1.4% and 0 % in NHL patients and control group respectively. The HCV-RTPCR positive results were detected in 11 out of 70)15.7%(and 6 out of 100)6%(in NHL patients and healthy control group respectively. For significant correlation of anti-HCV antibody titer and positive result of HCV-RT-PCR with NHL disorders manifestations, detection and monitoring of HCV infection parameters may have a role in malignant of therapeutic strategies in these lymphoma patients.