Effects of Soy Flour Enriched Bread Consumption on Plasma Lipid Profile and its Association with ApoE Genotype in Overweight and Obese Women

Soy products consumption may have favorable effects on cardiovascular diseases risk factors. These effects may be associated with the polymorphism in Apo E gene. To examine the effects of consumption of soy flour enriched bread on plasma lipids and its association with ApoE genotype in overweight and obese women. In this randomized cross-sectional clinical trial, 30 overweight and obese women received a mild weight loss diet and then, randomly assigned to a regular diet and a soy bread diet, each for 6 weeks and a washout period for 20-d. In the soy bread diet group, 120 gr of soy flour enriched bread was replaced by equal amount of usual bread intake. No significant effect of soy bread on lipid profile was observed when comparing the two groups (P <0.05). Evaluation of the effects of the two ApoE groups E2 (&epsilon 2/ &epsilon2) and E3 (&epsilon3/ &epsilon3 or &epsilon2/ &epsilon3) showed a significant effect of soy bread on TG in E2 group, compared to E3 group (P=0.02). Soy bread consumption has favorable effects on serum TG of overweight and obese women with &epsilon2 allele.