Effects of High Dose of HCG on Cryptorchidism Treatment and the Reduction of Necessity of Surgical Intervention in Boys between 1-3 Years of Age: A Randomized Double-Blind Clinical Trial

Introduction & In Cryptorchidism, testis is arrested in its normal path of descent. The importance of cryptorchidism is in its complications, such as: inguinal hernia, infertility, cancer, torsion of the spermatic cord and psychological disorders. The irreparable nature of some of these complications, show the necessity of more attention to the treatment of cryptorchidism. The aim of this study is to evaluate the effects of high dose of HCG (Human Chorionic Gonadotropin) on Cryptorchidism treatment and the reduction of the necessity of surgical intervention in boys between 1-3 years of age.
Our study included 70 cryptorchidic boys, between 1-3 years of age. Patients were divided into two groups (A and B). One group received 1500 IU of high dose of HCG three times weekly for 3 weeks. The second group also received placebo, three times weekly for 3 weeks. One month after the last injection, patients were evaluated with physical examination and ultra-sonography. The effect of HCG on testicular descent and size was examined. Finally, patients who were not treated underwent surgery. Finally, the data were analyzed by SPSS software, using descriptive statistical tests, chi-square ýtest, t test, and logistic regression.
A positive correlation was found between the rate of success and the testicular position. There was no relation between the HCG response and gestational age and the age at which treatment was initiated. Response to HCG treatment of cryptorchidism (Testicular descent and testicular size) was 80% (P Based on the findings of present study, HCG is effective in descension and enlargement of testis, so confirmation of this matter require complementary studies with larger sample size.