Genetically Overlap of Down Syndrome and Alzheimer's Disease

Down syndrome (DS) is a common chromosomal disorder that cause to mental retardation in children. Alzheimer’s disease (AD) is also common in DS. Therefore, it is assumed that there is a same genetic basis. The aim of this study was to study and consider the overlap of DS and AD.
In this review article, published articles in science direct, Pubmed, Willy and Google were investigated between 1990 and 2015.
Down syndrome is caused by trisomy 21. All genetic mutations in relation with AD are arising from accumulation of β amiloid. One of the genes involved in AD is APP that sited on chromosome 21. Moreover, the SOD1 also is sited on chromosome 21. Also, other hypothesis in relation with AD and DS has been considered. Significant percent of individual with DS are with AD, but its cause is not clear.